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Injectable suspension

Composition: Each 1 ml contains:
Procaine Penicillin 200 mg
Dihydrostreptomycin Sulphate 250 mg
The combination of penicillin and dihydrostreptomycin is especially useful in the treatment of mixed infections involving both Gram-positive and Gram-negative organisms.
The spectrum of activity of penicillin G includes many aerobic and anaerobic gram- positive organisms. Penicillin G is highly susceptible to beta- lactamases and has little activity against organisms that can produce these enzymes. In addition, penicillin G is ineffective against bacteria that are resistant by certain other mechanisms, such as having a relatively impermeable cell wall. Therefore, penicillin G has little activity against many staphylococci and most gram- negative bacteria.
The penicillins produce their bactericidal effect by inhibiting cross- linkages during bacterial cell wall synthesis. Pencillin G must penetrate the cell wall to attach to specific proteins on the inner surface of the bacterial cell membrane.
In actively growing cells, the binding of penicillin within the cell wall leads to interference with production of cell wall peptidoglycans and subsequent lysis of the cell in a hypo- or iso- osmotic environment.
AVISTREP is indicated for use against infections caused by organisms susceptible to Penicillin or Streptomycin, which includes: Staphylococcus spp, Streptococcus spp. Pasteurella multocida, Pasteurella haemolytica, Corynebacterium pyogenes, Klebsiella pneumonia, Listeria spp, and Salmonella spp.
AVISTREP is effective in the treatment of both local and systemic diseases caused by susceptible organisms including: urogenital tract infections; respiratory tract infections e.g. pneumonia; listeriosis; meningitis; septicaemia; enteritis caused by Salmonella spp., toxaemia associated with mastitis; salmonellosis; Strangles; and the control of secondary bacterial infections.
Doses and Administration:
The dose should be given once daily by deep intramuscular injection for up to three consecutive days.
Cattle, horses, sheep, goats, dog and cat: 1 ml AVISTREP per 25 kg bodyweight (Equivalent to 8 mg procaine penicillin and 10 mg dihydrostreptomycin sulphate per kg b.wt.).
Suggested dosing table:



Horses & cows

10-15 ml daily

Foals, Sheep, and goats:

3-8 ml daily

Cats & dogs

0.2-2 ml daily

The Volume of administration should not exceed the following per site of injection:
15 ml in horses.
6 ml in cattle.
3 ml in sheep and goats.
Shake well before use.
Withdrawal period:
Meat: Cattle: 23 days.
Sheep: 31 days.
Milk: Not for use in animals producing milk for human consumption.
Contra-indicated in known cases of hypersensitivity to penicillins.
Store in a dark place at a temperature below 30 ºC.
20, 50 & 100 ml sterile glass bottles.