COLISTIN “AVICO”

POWDER

Composition: Each 1 gm contains:
Colistin (as Colistin sulphate) 600 000 IU
Properties:
Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganise the outer memb
rane of Gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the
anionic lipid a region, thereby neutralising the endotoxin capacity of LPS. Colistin sulphate is poorly absorbed
after oral administration, and serum concentrations are generally undetectable. In chickens, residues in serum were detectable for up to 6 hours after administration in the drinking water. Orally administered colistin is eliminated almost totally in faeces.
Indications:
COLISTIN “AVICO” Powder is indicated for the treatment of enteric infections caused by gram-negative bacteria e.g. E. coli, Salmonella, Shigella in poultry, calves and lambs.
Colistin are highly effective against strains of E. coli, Pseudomonas aeruginosa, Salmonella spp., Haemophilus spp., Shigella spp., Pasteurella spp., Brucella spp., Aerobacteraerogenes, and Bordetella bronchiseptica. Gram-positive bacteria are generally less sensitive. However, there are sensitive strains of Staphylococcus spp., Bacillus spp., Streptococcus pyogenes and Corynebacterium spp.
Dosage and Administration:
Poultry: 1 g per 1-2 Liter of drinking water for 5-7 days, or 1 kg per 0.5-1 ton of feed for 5-7 days.
Calves and Lambs: 2 g per 10 kg body weight for 3-6 days.
Withdrawal period:
Meat & Eggs: 7 days.
Storage:
Store in dark place and at a temperature below 30C.
Packaging:
100 gm Aluminum foil bag, 500 gm & 1 kg plastic bottles.

FOR VETERINARY USE ONLY