Composition:Each 1ml contains:
Trimethoprim 40 mg
Sulphadiazine Sodium 200 mg
COLIPRIM liquid is an oral solution composed of trimethoprim and Sulphadiazine. The action of the combination was proved to be bactericidal where as the component separately only bacteriostatic as trimethoprim potentates the antibacterial activity of Sulphadiazine against a wide range of Gram-positive and Gram-negative bacteria.
Sulphonamides act as an analogue for para-aminobenzoic acid, (PABA) which itself a part of the vitamin, folic acid. In organisms that synthesis their own folic acid, sulphonamides as sulphadiazine acts by blocking the synthesis of folic acid. Sulphonamides are active against bacteria but not against higher organisms as bacteria synthetic their own folic acid whereas higher animals or higher organisms obtained folic acid from the diet.
COLIPRIM liquid is a distinctive drug against a wide range of gram-positive and gram-negative bacteria, beside its bactericidal effects; it has an enzyme inhibiting activity. It is used in the treatment of various infectious diseases, e.g. pasteurellosis, colibacillosis and Salmonellosis in poultry and other animals and infectious coryza in poultry.
COLIPRIM liquid is a distinctive drug against a wide range of Gram-positive and Gram-negative bacteria such as E. coli, Salmonella, Klebsiella, Brucella, Corynebacterium pyogens, Pasteurella, Staphylococcus, Streplococcus, Enterobacter and Haemophilus.
Poultry: 2-4 ml per 5 liters of drinking water for 5 days.
Calves and lambs: 2 ml per 15 kg of live body weight per day orally for 5 days.
Withdrawal period:
Poultry: 5 days
calves and lambs: 14 days
Eggs: Not to be used in laying birds.
Contra-indications and warnings:
Not to be used for animals with functional rumen.
Store in a dark place at a temperature below 30º C.
100 and 500 ml and 1L bottles.