AVIPROL 24%

A water Soluble Powder for Oral Use

Composition:Each 1g contains:
Amprolium HCl 240 mg
Properties:
Amprolium is structurally similar to thiamine (vitamin B1) and is a competitive antagonist.
The action of Amprolium depends on its mimicry of thiamine and competition for absorption by the parasite. This occurs because of the close structural similarity of the two compounds.
Amprolium acts upon the early first generation schizonts and merozoites, so its use is predominantly prophylactic. Moreover, Amprolium acts by inhibition the uptaking of thiamine by the protozoan. In addition, because of the relatively high requirement of rapidly dividing Eimeria for thiamine, the drug has a wide safety margin (8: 1) when used at the highest recommended level in feed. Maximal effect occurs about the 3rd day of the life cycle of Eimeria. Evidence suggests that it is also suppresses to some degree the sexual stages (gametogony) and sporulation of the oocysts.
Indications:
AVIPROL 24% is used for prevention & treatment of coccidiosis in poultry, turkeys, calves and lambs.
AVIPROL 24% is the drug of choice against different types of Eimeria that cause Coccidiosis in chickens (layers, breeders and broilers), Turkeys, calves and lambs.
Doses and Administration:
Poultry: Prevention: 1 g AVIPROL 24% per 2 liters of drinking water for 7 - 14 days.
Treatment: 1 g AVIPROL 24% per 1 liter of drinking water for 5-7 days.
Other animals: 20-40 mg Amprolium per 1 kg body weight, daily for 4 –5 days.
(Equivalent to 85-170 mg Aviprol 24% per 1 kg body weight).
Withdrawal period:
Meat: 3 days.
Contraindications and Precautions:
Amprolium is a thiamine antagonist, so the continuous use of excessive levels of Amprolium doses may lead to thiamin deficiency. The addition of thiamine to the feed or drinking water would rapidly correct the condition.
Diets contain the normal levels of thiamine do not antagonize the anticoccidial ctivity of Amprolium.
Storage:
Store in a dark place at a temperature below 30C.
Packing:
100, 500 g and 1kg aluminum foil bag.

FOR VETERINARY USE ONLY