Water Soluble Powder For Oral Use

Composition: Each 1g contains:
Amprolium HCl 600 mg
Amprolium is structurally similar to thiamine (vitamin B1) and is a competitive antagonist.
The action of Amprolium depends on its mimicry of thiamine and competition for absorption by the parasite. This occurs because of the close structural similarity of the two compounds.
Amprolium acts upon the early first generation schizonts and merozoites, so its use is predominantly prophylactic. Moreover, Amprolium acts by inhibition the uptaking of thiamine by the protozoan. In addition, because of the relatively high requirement of rapidly dividing Eimeria for thiamine, the drug has a wide safety margin (8: 1) when used at the highest recommended level in feed. Maximal effect occurs about the 3rd day of the life cycle of Eimeria. Evidence suggests that it is also suppresses to some degree the sexual stages (gametogony) and sporulation of the oocysts.
Amprolium HCl, the active ingredient of Aviprol plus, is an antiprotozoal agent, which is used for prevention & treatment of coccidiosis in poultry, turkeys, calves and lambs. AVIPROL 60% is the drug of choice against different types of Eimeria that cause coccidiosis in layers, breeders and broilers.
Amprolium HCl is the only anticoccidial approved for use in laying birds.
Doses and Administration:
Poultry: Prevention: 50 g AVIPROL 60%per 250 liters of drinking water for 7 - 14 days.
Treatment: 100 g per 250 liters of drinking water for 5-7 days.
Calves & lambs: 5-10 mg per 1 kg body weight
Withdrawal period:
Poultry, Calves & lambs: 1 day.
Contraindications and Precautions:
Amprolium is a thiamine antagonist, so the continuous use of excessive levels of Amprolium doses may lead to thiamin deficiency. The addition of thiamine to the feed or drinking water would rapidly correct the condition.
Diets contain the normal levels of thiamine do not antagonize the anticoccidial activity of Amprolium.
Store in a dark place at a temperature below 30C.
100, 500 g and 1kg aluminum foil bag.