Composition:Each 1g contains:
Amprolium HCl 250mg
Ethopabate 16 mg
Amprolium and Ethopabate act synergistically against coccidian. Amprolium is structurally similar to thiamine (vitamin B1) and is a competitive antagonist.
The action of Amprolium depends on its mimicry of thiamine and competition for absorption by the parasite. This occurs because of the close structural similarity of the two compounds.
Amprolium acts upon the early first generation schizonts and merozoites, so its use is predominantly prophylactic. Moreover, Amprolium acts by inhibition the up taking of thiamine by the protozoan. In addition, because of the relatively high requirement of rapidly dividing Eimeria for thiamine, the drug has a wide safety margin about (8:1) when used at the highest recommended level in feed. Maximal effect occurs about the 3rd day of the life cycle of Eimeria. Evidence suggests that it is also suppresses to some degree the sexual stages (gametogony) and sporulation of the oocysts.
AVIPROL PLUS premix is indicated for the prevention of caecal and intestinal coccidiosis in chickens, turkeys and rabbits, as well as, the treatment of coccidiosis in calves and lambs. AVIPROL PLUS in chickens provides efficacy of amprolium against Eimeria tenella, E. acervulina and increased activity against E. necatrix, E. maxima, E. mitis and some strains of E. brunetti.
Doses and Administration:
Poultry: Layers: 0.5 kg AVIPROL Plus per 1 ton of feed continuously.
Broilers: 1 kg AVIPROL Plus per 1 ton of feed continuously.
Calves and lambs: 0.16 – 0.32 gm AVIPROL Plus per 1 kg of body weight for 5 – 7 days.
Withdrawal period:
Meat: 3 days.
Store in a dark place at temperature below 30 C.
100, 500 g and 1kg aluminum foil bag.