AVICORT Inj.

Corticosteroid Injection

Composition: Each 1 ml contains:
Dexamthasone Sodium Phosphate 2 mg.

Properties: Dexamethasone is readily absorbed into tissue, and rapidly distributed to kidneys, liver, muscle, and intestines. It is metabolized in the liver and primarily excreted by the kidneys. Dexamethasone is a synthetic analogue of prednisolone, which has more potent anti-inflammatory properties and multiple hormonal and metabolic properties. Modification in dexamethasone offers enhanced anti-inflammatory effect compared to older corticosteroids. The dosage of dexamethasone required is markedly lower than that of prednisone and prednisolone.
Dexamethasone stimulates synthesis of enzymes required to decrease the inflammatory response. Its primary efficacy is that of a strong anti-inflammatory, as well as an antialleric agent.
Besides being an anti-inflammatory, the drug will also suppress the immune response; stimulate bone marrow and influence fat, protein, and carbohydrate metabolism.
Dexamethasone is a long acting florinated glucorticoid with 25-30 times more potency than an equal weight of hydrocortisone. It is faster acting with longer duration than the intermediate oral agents prednisone and prednisolone.

Indications:
AVICORT is used as an anti-inflammatory agent in cattle, horses, cats & dogs. Also used as an aid in the treatment of primary bovine ketosis. May be it used as supportive therapy in mastitis, metritis, traumatic gastritis, and pyelonephritis, while appropriate primary therapy is administered. In these cases, the corticosteroid combats accompanying stress and enhances the feeling of general well-being. Dexamethasone may also be used as supportive therapy in inflammatory conditions, such as snakebite, acute mastitis, shipping fever, and pneumonia.
Used intravenously in cases where emergency treatment is indicated, particularly shock and circulatory collapse, and burns.
Indications also include inflammatory conditions involving the joints (where bony changes and structural changes such as ankylosing joints, ruptured ligaments, sheaths, do not exist) and allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids including nonspecific dermatitis.
Equine indications include the treatment of acute musculoskeletal inflammations; bursists, carpitis, tendinitis, myositis, sprains and as supportive therapy in fatigue, heat exhaustion and acute infectious diseases, and laminitis, also could be used in retained placenta provided primary cause is diagnosed and treated.

Doses and administration:

  • By intravenous or intramuscular injection.
  • Horses & cattle: 1 ml per 25 kg body weight (80 mg/kg body weight), the dose could be repeated if necessary.
  • Dogs & cats: 1 ml per 10 kg body weight (200 mg/kg body weight), the dose could be repeated if necessary.
  • For shock only: give 2-2.5 ml/kg (4 - 6 mg/ kg) Sub-Cutaneous, Intra-Muscular, Intra-Periotoneal.

Withdrawal period:
Meat: 21 days.
Milk: 7 days.

Contra-indications:

  • Contraindicated in animals with renal disease and diabetes mellitus.
  • Not to be used in viraemia stage.
  • Not recommended for use in pregnant animals. Administration in late pregnancy may cause early parturition or abortion.
  • Not recommended to use in animals with systemic fungal infection.

 

Special precautions & untoward reactions:

 

Use of the product in horses could induce laminitis and therefore careful observations during treatment should be made.
Corticosteroids may delay wound healing and the immunsuppressant actions may weaken resistance to or exacerbate existing infections, thus, anti-bacterial drug cover is usually required when steroids are used.
In prolonged treatment care should be taken to withdraw dose gradually.
Close veterinary supervision should be available during treatment.

Storage:
Store in a dark place at a temperature below 30°C.

Packing:
50 ml and 100 ml amber glass bottles.

FOR VETERINARY USE ONLY