AVICO

Your Way to AnimalHealth

AVICO

Specializing in Veterinary Products since 1978

AVICO

Promoting Excellenc Quality Through R&D

AVICO

Available in 21 Countries Around The World

AVIMEC SUPER

INJECTION

Composition:Each 1ml contains:
Ivermectin 10 mg
Clorsulon 100 mg

Properties:
Ivermectin against the parasites is related to the inhibition of the parasite motility. B1a apparently increases the release of -aminobutyric acid (GABA) from the synaptosomes of the nervous system. The normal function of GABA in tested mammals and invertebrates is inhibition of neurotransmission.
Increasing release of GABA increases the normal resting potential of postsynaptic cells making it difficult for neurotransmission of stimuli to muscles and muscle cells do not contract.
Although paralysis is the most evident effect of Ivermectin, suppression of the reproductive function has been observed in ticks. It does not result in prompt death or detachment of ticks but does interrupt feeding, molting and egg production, so that reducing the reproductive potential of ticks.
Ivermectin displays no activity against cestodes or trematodes due to these parasites do not utilize GABA as a neurotransmitter.
Clorsulon inhibits the enzymes implicated in the glycolytic pathway, source of energy in flukes. Further investigations indicated that clorsulon is a competitive inhibitor of 8- phosphoglycerate kinase and phospho-glyceromutase and blocks the oxidation of glucose to acetate and propionate. Clorsulon also depresses ATP levels in the fluke.

Indications:
For the treatment of roundworms, parafilaria, adult liver fluke, lice, mange mite, sandtampans, blue-ticks, screwworm, eye worm and residual activity against the reinfestation of roundworms in cattle.
For the treatment of roundworms, nasal worm, adult liver fluke, Australian itch mite and scab mite in sheep.

Doses:
Cattle: 1 ml per 50 kg body weight
Choose the dose according to weight of the heaviest animals. Use the following dosage schedule:

Body Dose Dose per Pack      
weight  volume        
(kg) (ml) 10 ml) (20 ml) (50 ml) (100 ml)
Up to 50  1 10 20 50 100
51-100 2 5 10 25 50
101-150 3 3 6 16 33
151-200 4 2 5 12 25
201-250 5 2 4 10 20
251-300 6 1 3 8 16
301-350 7 1 2 7 14
351-400 8 1 2 6 12
401-450 9 1 2 5 11
451-500 10 1 2 5 10
501-550 11 - 1 4 9
551-600 12 - 1 4 8

Heavier animals (e.g., Mature bulls) should receive an additional 1 ml for each 50 kg over
600 kg body weight.

Sheep:
0.5 ml per 25 kg body weight
Choose the dose according to weight of the heaviest animals. Use the following dosage schedule:

Body Dose Dose per Pack      
weight  volume         
(kg) (ml) (10 ml) (20 ml) (50 ml) (100 ml)
Up to 25  0.5 20 40 100 200
26-50 1 10 20 50 100
51-57 1.5 6 13 33 66
76-100 2 5 10 25 50

Heavier animals should receive an additional 0.5 ml for each 25 kg over 100 kg.
Check the accuracy of injection gun before use.

Administration:
Cattle: Inject under the loose skin in front of or behind the shoulder. The recommended use level had no adverse effect on the breeding performance of cattle.
Sheep: Inject under the loose skin behind the shoulder, the axilla or on the inside of the thigh. Ensure that the needle is carefully inserted and that the solution does not leak from the injection site. Make certain that the needle has penetrated the wool and skin before delivering the dose. The recommended use level had no adverse effects on the breeding performance of sheep.

Withdrawal period:
Meat: Cattle and sheep: 35 days.
Milk: not for use in lactating animals.

Contraindications and Precautions:
Do not administer intravenously or intramuscularly.

Note for users:
Transitory discomfort and a swelling at the site of injection have been observed in some cattle and sheep following subcutaneous administration. These reactions have disappeared without treatment few days later. When a dose greater than 10 ml should be administered, then the dose must be divided and injected into two different sites.

Storage:
Store in a dark place at a temperature below 30 º C.

Packing:
10 ml, 20 ml, 50 ml and 100 ml amber glass bottles.
10 ml, 20 ml, 50 ml and 100 ml plastic bottles.

For Veterinary Use only