IVECLOSA

IVECLOSA

Injection

Composition:
Each 1 ml contains:
Closantel (as Closantel Sodium Dihydrate) 125 mg
Ivermectin 5 mg
Properties:
IVECLOSAis a member of the salicylanilide class of anthelmintics. Salicylanilides are hydrogen (proton) ionophores (Referred to as oxidative phosphorylase uncouplers.)
The chemical structure of salicylanilides illustrates the possession of a detachable proton. This type of molecule is lipophilic and is known to shuttle protons across membranes, in particular the inner mitochondrial membrane.
Closantel acts by uncoupling oxidative phosphorylation.
Closantel is a parasiticide with flukicide activity and efficacy against certain other helminths and arthropods.
Ivermectin is effectively treatment & control internal and external parasites in Cattle and Sheep, Ivermectin is derived from the family avermectins, which are isolated from fermentation of the soil organism Streptomyces avermitilis.
Ivermectin paralyzes and ultimately kills parasitic nematodes, arachnoids, and insects by a unique effect on the nervous systems of these parasites.
Ivermectin action is due to a neurotransmitter chemical that serves as a signal from one nerve cell to another or from a nerve cell to a muscle cell and is called gamma amino butyric acid (GABA), In round worms Ivermectin stimulates the release of GABA from nerve endings and enhances binding of GABA to a special receptors at nerve Junctions, thus interrupting nerve impulses and leading to paralysis and death of the parasite. The same effect occurs in mites & lice.
Ivermectin has no effect on acetylcholine which is the principal peripheral neurotransmitter in mammals and does not readily penetrate the central nervous system of mammals were GABA functions as neurotransmitter.
Indication:
IVECLOSA is indicated for the treatment of internal and external parasites in Cattle and Sheep.
Cattle: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.
Sheep: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, nasal bots and mites of sheep.
Dosage & administration:
ingle dose by subcutaneously injection.
Cattle & Sheep:1 ml per 25 kg body weight.
(Equivalent 200 μg Ivermectin per 1 kg b.wt. and 5 mg closantel per 1 kg b.wt.)
- For the treatment and control of sheep scab can be repeated after 7 days.
Note:Do not administer more than 10 ml in one injection site.
Withdrawal Period:
Cattle:49 days.
Sheep:28 days.
Milk:Do not use in animals producing milk for human consumption.
Precautions:
- IVECLOSAis not for intravenous or intramuscular injection.
Storage:
Store in a dark place at a temperature below 25C.
Packing:
20, 50 & 100 ml amber glass injection bottles.

FOR VETERINARY USE ONLY