AVICO

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AVICO

Specializing in Veterinary Products since 1978

AVICO

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AVICO

Available in 21 Countries Around The World

TRYBAN

Trypanocidal for Injection

Composition: Each 2.5 gm contains;

Quinapyramine Sulphate 1.5 gm

Quinapyramine Chloride 1 gm

Properties:
TRYBAN is composed of both Quinapyramine salts (Sulphate and Chloride) which differ in their absorption and action in the body; the Sulphate salt is water soluble to which the curative action of TRYBAN could be attributed, and the chloride salt which is less soluble forming a depot at the site of injection, it is absorbed slowly and the prophylactic action could be attributed.

Indications:
TRYBAN is effective in prevention and treatment of trypanomisis in camels, cattle, horses, dogs & pigs. Caused by different Ttypanosoma spp. T. evansi, T. con golense, T. vivax, T. brucei, T. equinum, T. equiperdeum and T. simiae.

Dosage and Administration: 

Add 15 ml water for injection to the bottle, shake to reconstitute the suspension.
The recommended dose for animals is 0.025 ml per kg body weight subcutaneous route. Which is (Equivalent to Quinapyramine Sulphate: 2.5 mg/kg b. wt. and Quinapyramine Chloride l.67 mg/kg b. wt.). TRYBAN injection should be administered subcutaneously using sterile syringes and needles and employing an aseptic technique.
Massage at the site of injection is good to disperse the drug and minimise the risk of local reactions.
In debilitated animals TRYBAN should be reconstituted to 30 ml and dose be divided up to 12 hourly installments.
In areas where Nagana and Surra are endemic, herds should be given TRYBAN prophylactically every 2-3 months.
For horses it is advisable to dilute to 30 ml and be given intramuscularly into two or three injections at different sites.
Practical dosing table:

Body wt. (Kg)

Vol. (ml)

Body wt. (Kg)

Vol. (ml)

Body wt. (Kg)

Vol. (ml)

10

0.25

50

1.25

300

7.50

20

0.50

100

2.50

400

10.0

30

0.75

150

3.75

500

12.5

40

1.00

200

5.00

600

15.0

Special precautions:
Weight of the animal need to be assessed as accurately as possible especially young animals.
Shake well before use, and use immediately upon reconstitution.
Don’t Store the reconstituted suspension.

Withdrawal period:
Meat: 21 days.
Milk: 4 days.

Untoward reactions:
Upon correct assessment of body weight and dosing, side effects are less likely to occur, however, salivation, restlessness and tremors at the site of injection had been observed in some susceptible animals. These signs are only transitory and need resting of the animal in a quite place.

Overdosage:
Toxicity is not so important as with other trypanocidals, except in young animals where over dosage may cause sweating, salivation, trembling and followed in severe cases by an increase in heart rate and respiration, collapse and possibly death.
In cow some time rusty colored diarrhea might be observed. The chloride salt is absorbed very much more slowly than the sulphate and used by itself is non toxic.

Storage:
Store in a dark place at a temperature below 30 º C.

Packing:
2.5 gm injectable powder in amber glass bottles to be dissolved in 15 ml.
2.5 gm injectable powder in aluminum foil sachets to be dissolved in 15 ml.

FOR VETERINARY USE ONLY